Abstract Coptis Chinensis Franch is widely used in the treatment of diabetes, and berberine
is the primary bioactive component in it. Evidence from previous studies has shown that …

Ski and the closely related SnoN were discovered as oncogenes by their ability to transform
chicken embryo fibroblasts upon overexpression. While elevated expressions of Ski and …

Streptococcus salivarius is an early colonizer of human oral and nasopharyngeal epithelia,
and strain K12 has reported probiotic effects. An emerging paradigm indicates that …

Although some long noncoding RNA s (lnc RNA s) have been shown to regulate gene
expression in cis, it remains unclear whether lnc RNA s can directly regulate transcription in …

Many intergenic long noncoding RNA (lncRNA) loci regulate the expression of adjacent
protein coding genes. Less clear is whether intergenic lncRNAs commonly regulate …

The transforming growth factor-β (TGF-β) family plays major pleiotropic roles by regulating
many physiological processes in development and tissue homeostasis. The TGF-β signaling …

Axonal growth is fundamental to the establishment of neuronal connectivity in the brain.
However, the cell-intrinsic mechanisms that govern axonal morphogenesis remain to be …

Protein post-translational modification by the small ubiquitin-like modifier (SUMO) regulates
the stability, subcellular localization, and interactions of protein substrates with …

Recurrent copy number variations (CNVs) are genetic alterations commonly observed in
human tumors. One of the most frequent CNVs in human tumors involves copy number …

Mutations in the microtubule (MT)-binding protein doublecortin (DCX) or in the MT-based
molecular motor dynein result in lissencephaly. However, a functional link between DCX …