Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes …

Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays
considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting …

Medulloblastoma, a small blue cell malignancy of the cerebellum, is a major cause of
morbidity and mortality in pediatric oncology. Current mechanisms for clinical …

Genomic rearrangements are thought to occur progressively during tumor development.
Recent findings, however, suggest an alternative mechanism, involving massive …

The division of medulloblastoma into different subgroups by microarray expression profiling
has dramatically changed our perspective of this malignant childhood brain tumour. Now …

Purpose Reports detailing the prognostic impact of TP53 mutations in medulloblastoma offer
conflicting conclusions. We resolve this issue through the inclusion of molecular subgroup …

Purpose Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group
3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical …

Medulloblastomas that display a large cell/anaplastic morphology and overexpress the
cellular c-MYC gene are highly aggressive and carry a very poor prognosis. This so-called …

Medulloblastoma, the most common malignant paediatric brain tumour, is currently
diagnosed and stratified using a combination of clinical and demographic variables. Recent …