The regulation of gene expression is fundamental for life. Whereas the role of transcriptional
regulation of gene expression has been studied for several decades, it has been clear over …

ATP-binding cassette (ABC) transporters use the energy of ATP hydrolysis to transport a
large diversity of molecules actively across biological membranes. A combination of …

A key step in translational initiation is the recruitment of the 43 S preinitiation complex by the
cap-binding complex [eukaryotic initiation factor 4F (eIF4F)] at the 5′ end of messenger …

In eukaryotic translation, termination and ribosome recycling phases are linked to
subsequent initiation of a new round of translation by persistence of several factors at …

In higher eukaryotes, the mRNA sequence in the direct vicinity of the start codon, called the
Kozak sequence (CRCCaugG, where R is a purine), is known to influence the rate of the …

The use of fluorescence techniques has an enormous impact on various research fields
including imaging, biochemical assays, DNA‐sequencing and medical technologies. This …

Stringent targeting of membrane proteins to corresponding organelles is essential for
organelle identity and functions. In addition to molecular pathways that target proteins to …

Converting genetic information into functional proteins is a complex, multi-step process, with
each step being tightly regulated to ensure the accuracy of translation, which is critical to …

Novel biophysical tools allow the structural dynamics of proteins and the regulation of such
dynamics by binding partners to be explored in unprecedented detail. Although this has …

Protein biosynthesis is a conserved process, essential for life. Ongoing research for four
decades has revealed the structural basis and mechanistic details of most protein …