The synaptic vesicle cluster as a controller of pre‐and postsynaptic structure and function

S Reshetniak, CA Bogaciu, S Bonn… - The Journal of …, 2024 - Wiley Online Library
The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which
provides neurotransmitter‐loaded vesicles during synaptic activity, at the same time as also …

Synaptotagmin-1 undergoes phase separation to regulate its calcium-sensitive oligomerization

M Zhu, H Xu, Y Jin, X Kong, B Xu, Y Liu, H Yu - Journal of Cell Biology, 2024 - rupress.org
Synaptotagmin-1 (Syt1) is a calcium sensor that regulates synaptic vesicle fusion in
synchronous neurotransmitter release. Syt1 interacts with negatively charged lipids and the …

Blobby is a synaptic active zone assembly protein required for memory in Drosophila

J Lützkendorf, T Matkovic-Rachid, S Liu, T Götz… - Nature …, 2025 - nature.com
At presynaptic active zones (AZs), scaffold proteins are critical for coordinating synaptic
vesicle release and forming essential nanoarchitectures. However, regulatory principles …

Intracellular protein-lipid interactions drive presynaptic assembly prior to neurexin recruitment

EB Frankel, A Tiroumalechetty, Z Su, PS Henry… - Neuron, 2025 - cell.com
Neurexin cell-adhesion molecules regulate synapse development and function by recruiting
synaptic components. Here, we uncover a mechanism for presynaptic assembly that …

Identification and characterization of a synaptic active zone assembly protein

J Luetzkendorf, T Matkovic, T Goetz, S Liu, T Ghelani… - bioRxiv, 2024 - biorxiv.org
At presynaptic active zones (AZs), scaffold proteins play a crucial role in coordinating
synaptic vesicle (SV) release and forming intricate nanoarchitectures essential for synaptic …

A Blueprint of Sex-Specific Neuronal Regulation in the C. elegans Nervous System at Single-Cell Resolution

R Haque, H Setty, R Lorenzo, G Stelzer, R Rotkopf… - bioRxiv, 2024 - biorxiv.org
Sex-specific behaviors within a species are often attributed to variances in neuronal wiring
and molecular signatures. However, how the genetic sex shapes the molecular architecture …

The role of liprin-α1 phosphorylation in its liquid-liquid phase separation: regulation by PPP2R5D/PP2A holoenzyme

A Mayer, R Derua, E Spahn, I Verbinnen, Y Zhang… - bioRxiv, 2024 - biorxiv.org
Liprin-alpha1 is a widely expressed scaffolding protein responsible for regulating cellular
processes such as focal adhesion, cell motility, and synaptic transmission. Liprin-alpha1 …

[图书][B] Molecular mechanisms of human presynapse assembly-role of liprin-alpha proteins in synapse organization and neurological disease

MC Berta - 2024 - gupea.ub.gu.se
Synapses are the essential transmission units of neuronal circuits and represent the
cornerstone of our unique cognitive abilities. During synapse formation, contact between two …

Wee1 and Cell Size Control in Fission Yeast by the Protein Kinase Cdr2

R Berg-Murante - 2024 - search.proquest.com
The mechanisms that govern cell size have long been topics of study in the field of cell
biology. In eukaryotic cells this size control is tied to checkpoints, a set threshold of minimum …