Ewing's sarcoma family tumors (EFT) are characterized by specific chromosomal
translocations, which lead to EWS/ETS transcription factors. Elucidation of EWS/ETS target …

Ewing sarcoma is an aggressive bone malignancy that affect children and young adults.
Ewing sarcoma is the second most common primary bone malignancy in pediatric patients …

Cancer cells must overcome anoikis (detachment-induced death) to successfully
metastasize. Using proteomic screens, we found that distinct oncoproteins upregulate IL1 …

Transcription factor fusion proteins can transform cells by inducing global changes of the
transcriptome, often creating a state of oncogene addiction. Here, we investigate the role of …

Deciphering the ways in which somatic mutations and germline susceptibility variants
cooperate to promote cancer is challenging. Ewing sarcoma is characterized by fusions …

Cancer stem cells (CSCs) display plasticity and self-renewal properties reminiscent of
normal tissue stem cells, but the events responsible for their emergence remain obscure. We …

Summary EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a
cascade of signaling events leading to cell transformation. However, it remains elusive how …

Many cancers are characterized by gene fusions encoding oncogenic chimeric transcription
factors (TFs) such as EWS:: FLI1 in Ewing sarcoma (EwS). Here, we find that EWS:: FLI1 …

Ewing sarcoma is an undifferentiated small-round-cell sarcoma. Although molecular
detection of pathognomonic EWSR1-ETS fusions such as EWSR1-FLI1 enables definitive …

Ewing sarcoma (EwS) is a highly metastatic bone cancer characterized by the ETS fusion
oncoprotein EWS-FLI1. EwS cells are phenotypically highly plastic and switch between …