Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic
metabolism. However, their proliferation is marked by a shift towards increasing glycolytic …

Age-associated neurological diseases represent a profound challenge in biomedical
research as we are still struggling to understand the interface between the aging process …

Pluripotent stem cells (PSCs) are characterized by their unique capacity for both unlimited
self-renewal and their potential to differentiate to all cell lineages contained within the three …

The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …

Ageing is associated with the functional decline of all tissues and a striking increase in many
diseases. Although ageing has long been considered a one-way street, strategies to delay …

The maintenance of cellular identity requires continuous adaptation to environmental
changes. This process is particularly critical for stem cells, which need to preserve their …

Reprogramming somatic cells to a pluripotent state drastically reconfigures the cellular
anabolic requirements, thus potentially inducing cancer-like metabolic transformation …

Recent studies link changes in energy metabolism with the fate of pluripotent stem cells
(PSC s). Safe use of PSC derivatives in regenerative medicine requires an enhanced …

The ability to reprogram adult somatic cells back to pluripotency presents a powerful tool for
studying cell-fate identity and modeling human disease. However, the reversal of cellular …

The discovery of induced pluripotent stem cells (iPSCs) a decade ago, which we are
celebrating in this issue of Cell, represents a landmark discovery in biomedical research …