Effects of acute alcohol on excitability in the CNS

NL Harrison, MJ Skelly, EK Grosserode, DC Lowes… - …, 2017 - Elsevier
Alcohol has many effects on brain function and hence on human behavior, ranging from
anxiolytic and mild disinhibitory effects, sedation and motor incoordination, amnesia …

Alcohol as an early life stressor: Epigenetics, metabolic, neuroendocrine and neurobehavioral implications

S Ciafrè, G Ferraguti, A Greco, A Polimeni… - Neuroscience & …, 2020 - Elsevier
Ethanol exposure during gestation is an early life stressor that profoundly dysregulates
structure and functions of the embryonal nervous system, altering the cognitive and …

Effects of pre-natal alcohol exposure on hippocampal synaptic plasticity: Sex, age and methodological considerations

CJ Fontaine, AR Patten, HM Sickmann, JL Helfer… - Neuroscience & …, 2016 - Elsevier
The consumption of alcohol during gestation is detrimental to the developing central
nervous system (CNS). The severity of structural and functional brain alterations associated …

Acute effects of ethanol on glutamate receptors

T Möykkynen, ER Korpi - Basic & clinical pharmacology & …, 2012 - Wiley Online Library
Several studies have revealed that acute ethanol inhibits the function of glutamate receptors.
Glutamate receptor‐mediated synaptic plasticity, such as N‐methyl‐d‐aspartate‐dependent …

[HTML][HTML] Focus on: neurotransmitter systems

CF Valenzuela, MP Puglia, S Zucca - Alcohol Research & Health, 2011 - ncbi.nlm.nih.gov
Neurotransmitter systems have been long recognized as important targets of the
developmental actions of alcohol (ie, ethanol). Short-and long-term effects of ethanol on …

Neonatal binge alcohol exposure increases microglial activation in the developing rat hippocampus

KE Boschen, MJ Ruggiero, AY Klintsova - Neuroscience, 2016 - Elsevier
Aberrant activation of the developing immune system can have long-term negative
consequences on cognition and behavior. Teratogens, such as alcohol, activate microglia …

Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure

ML Kleiber, K Mantha, RL Stringer… - Journal of …, 2013 - Springer
Background Maternal alcohol consumption is known to adversely affect fetal
neurodevelopment. While it is known that alcohol dose and timing play a role in the …

Neurotrophins in the brain: interaction with alcohol exposure during development

KE Boschen, AY Klintsova - Vitamins and hormones, 2017 - Elsevier
Fetal alcohol spectrum disorders (FASDs) are a result of the teratogenic effects of alcohol on
the developing fetus. Decades of research examining both individuals with FASDs and …

Determinants of novel object and location recognition during development

SA Jablonski, WB Schreiber, SR Westbrook… - Behavioural brain …, 2013 - Elsevier
In the novel object recognition (OR) paradigm, rats are placed in an arena where they
encounter two sample objects during a familiarization phase. A few minutes later, they are …

Long-term genomic and epigenomic dysregulation as a consequence of prenatal alcohol exposure: a model for fetal alcohol spectrum disorders

ML Kleiber, EJ Diehl, BI Laufer, K Mantha… - Frontiers in …, 2014 - frontiersin.org
There is abundant evidence that prenatal alcohol exposure leads to a range of behavioral
and cognitive impairments, categorized under the term fetal alcohol spectrum disorders …