Preeclampsia: pathophysiology, challenges, and perspectives

S Rana, E Lemoine, JP Granger… - Circulation …, 2019 - Am Heart Assoc
Hypertensive disorders of pregnancy—chronic hypertension, gestational hypertension, and
preeclampsia—are uniquely challenging as the pathology and its therapeutic management …

Combined diffusion‐relaxometry microstructure imaging: Current status and future prospects

PJ Slator, M Palombo, KL Miller… - Magnetic resonance …, 2021 - Wiley Online Library
Microstructure imaging seeks to noninvasively measure and map microscopic tissue
features by pairing mathematical modeling with tailored MRI protocols. This article reviews …

Combined diffusion‐relaxometry MRI to identify dysfunction in the human placenta

PJ Slator, J Hutter, M Palombo… - Magnetic resonance …, 2019 - Wiley Online Library
Purpose A combined diffusion‐relaxometry MR acquisition and analysis pipeline for in vivo
human placenta, which allows for exploration of coupling between and apparent diffusion …

Functional imaging of the human placenta with magnetic resonance

N Siauve, GE Chalouhi, B Deloison, M Alison… - American journal of …, 2015 - Elsevier
Abnormal placentation is responsible for most failures in pregnancy; however, an
understanding of placental functions remains largely concealed from noninvasive, in vivo …

T2* placental magnetic resonance imaging in preterm preeclampsia: an observational cohort study

AEP Ho, J Hutter, LH Jackson, PT Seed, L Mccabe… - …, 2020 - Am Heart Assoc
Placental dysfunction underlies the cause of pregnancies complicated by preeclampsia. The
use of placental magnetic resonance imaging to provide an insight into the pathophysiology …

Placenta microstructure and microcirculation imaging with diffusion MRI

PJ Slator, J Hutter, L McCabe… - Magnetic resonance …, 2018 - Wiley Online Library
Purpose To assess which microstructural models best explain the diffusion‐weighted MRI
signal in the human placenta. Methods The placentas of nine healthy pregnant subjects …

[HTML][HTML] The haemodynamics of the human placenta in utero

NS Dellschaft, G Hutchinson, S Shah, NW Jones… - PLoS …, 2020 - journals.plos.org
We have used magnetic resonance imaging (MRI) to provide important new insights into the
function of the human placenta in utero. We have measured slow net flow and high net …

[HTML][HTML] In vivo noninvasive systemic myography of acute systemic vasoactivity in female pregnant mice

K Huda, DJ Lawrence, W Thompson… - Nature …, 2023 - nature.com
Altered vasoactivity is a major characteristic of cardiovascular and oncological diseases,
and many therapies are therefore targeted to the vasculature. Therapeutics which are …

[HTML][HTML] Data-Driven multi-Contrast spectral microstructure imaging with InSpect: INtegrated SPECTral component estimation and mapping

PJ Slator, J Hutter, RV Marinescu, M Palombo… - Medical image …, 2021 - Elsevier
We introduce and demonstrate an unsupervised machine learning technique for
spectroscopic analysis of quantitative MRI experiments. Our algorithm supports estimation of …

Two‐Compartment Perfusion MR IVIM Model to Investigate Normal and Pathological Placental Tissue

A Maiuro, G Ercolani, F Di Stadio… - Journal of Magnetic …, 2024 - Wiley Online Library
Background Perfusion and diffusion coexist in the placenta and can be altered by
pathologies. The two‐perfusion model, where f 1 and, f 2 are the perfusion‐fraction of the …