Introduction: Children with neuroblastoma have widely divergent outcomes, ranging from
cure in> 90% of patients with low risk disease to< 50% for those with high risk disease …

Myc expression is deregulated in a wide range of human cancers and is often associated
with aggressive, poorly differentiated tumors. The Myc protein is a transcription factor that …

SUMMARY 1 An antisense oligonucleotide (ASO) is a short strand of deoxyribonucleotide
analogue that hybridizes with the complementary mRNA in a sequence‐specific manner via …

Mutations in the PTEN, TP53, and RB1 pathways are obligate events in the pathogenesis of
human glioblastomas. We induced various combinations of deletions in these tumor …

Simple Summary Neuroblastoma is one of the most diffuse and the deadliest cancer in
children. While many advances have been made in the last few decades to improve patients' …

Background Inner ear supporting cells (SCs) in the neonatal mouse cochlea are a potential
source for hair cell (HC) regeneration, but several studies have shown that the regeneration …

Survival rates of pediatric brain tumor patients have significantly improved over the years
due to developments in diagnostic techniques, neurosurgery, chemotherapy, radiotherapy …

Neuroblastoma is a pediatric malignancy characterized by tremendous clinical
heterogeneity, in which some tumors are extremely aggressive while others spontaneously …

Previous studies have indicated the important roles of MYCN in tumorigenesis and
progression of neuroblastoma (NB), the most common extracranial solid tumor derived from …

Purpose: Rhabdomyosarcomas are a major cause of cancer death in children, described
with MYCN amplification and, in the alveolar subtype, transcription driven by the PAX3 …