Objective: The first 70 years of critical care can be considered a period of “industrial
revolution-like” advancement in terms of progressing the understanding and care of critical …

Infective endocarditis (IE), initially described more than 350 years ago, involves infection of
the endocardial surface of the heart. The clinical manifestations of IE can involve every …

Ventricular assist device has rapidly emerged as a durable and safe therapy for end-stage
heart failure patients with> 22 000 implantations to date. Though originally conceived for …

Over 25 years ago, it became clear that heart transplantation would become a treatment
option for only a limited group of carefully selected patients with advanced heart failure (HF) …

There are only 2 treatments for the thousands of patients who progress to the most
advanced form of heart failure despite the application of guideline-based medical therapy …

There is considerable interest in the use of bacteriophages (phages) to treat Pseudomonas
aeruginosa infections associated with left ventricular assist devices (LVADs). These …

With the rising prevalence of heart disease in the United States, there is increasing reliance
on durable mechanical circulatory support (MCS) to treat patients with end-stage heart …

Background Left ventricular assist devices (LVADs) improve quality of life in end-stage heart
failure but can cause serious complications such as infections with driveline infection …

Cornwell et al Impact of LVADs on Brain Physiology and Outcomes 543 between the degree
of pulsatility and the rate of nonsurgical bleeding, 15 and the rate of thromboembolic events …

Background Left ventricular assist device (LVAD)–associated infections may be life-
threatening and impact patients' outcome. We aimed to identify the characteristics, risk …