Discusses the development of the immune system during pregnancy and early life. Cell
populations and their role in the allergic response; Development of immune competence; …

The components of the immune system have not been traditionally emphasized as potential
target organs in standard developmental and reproductive toxicity (DART) protocols. A …

B cell immunoglobulin production is regulated by helper T cells through direct interaction
and secreted cytokines. In the present study, we functionally analyzed CD27 in cord and …

Publisher Summary This chapter focuses on two sets of molecules involved in the
proliferation and differentiation of highly purified human B lymphocytes: the molecules …

Completely revised and updated, Developmental and Reproductive Toxicology: A Practical
Approach, Second Edition draws together valuable information typically scattered …

We have isolated low-density, nonadherent, nonphagocytic, HLA-DR+ ve cells with the
morphology of dendritic cells (DCs) from the cord blood of full-term newborn infants. Relative …

Identifying critical windows in immune system development is crucial for determination of
either safety or vulnerability to exposure to specific agents during rapidly changing phases …

The fetal immune system is highly specialized which is to generate both tolerogenic and
protective immune responses to tolerate both self-and maternal-antigens. Fetal T cells with …

Disease relapse is a barrier to achieving therapeutic success after unrelated umbilical cord-
blood transplantation (UCBT) for B-lineage acute lymphoblastic leukemia (B-ALL). While …

Neonatal and infant immune responses are characterized by a limited capability to generate
protective Ab titers and memory B cells as seen in adults. Multiple studies support an …