Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses

LA Costa, N Eiro, M Fraile, LO Gonzalez, J Saá… - Cellular and Molecular …, 2021 - Springer
Mesenchymal stem cells (MSC) are present in all organs and tissues. Several studies have
shown the therapeutic potential effect of MSC or their derived products. However, the …

Exosomes—beyond stem cells for restorative therapy in stroke and neurological injury

ZG Zhang, B Buller, M Chopp - Nature Reviews Neurology, 2019 - nature.com
Stroke is a leading cause of disability worldwide, and brain injuries devastate patients and
their families, but currently no drugs on the market promote neurological recovery. Limited …

Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine

FJ Vizoso, N Eiro, S Cid, J Schneider… - International journal of …, 2017 - mdpi.com
Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to
their capacity for local engrafting and differentiating into multiple tissue types. However …

Neuroinflammation and scarring after spinal cord injury: therapeutic roles of MSCs on inflammation and glial scar

QM Pang, SY Chen, QJ Xu, SP Fu, YC Yang… - Frontiers in …, 2021 - frontiersin.org
Transected axons are unable to regenerate after spinal cord injury (SCI). Glial scar is
thought to be responsible for this failure. Regulating the formation of glial scar post-SCI may …

Exosomes/miRNAs as mediating cell-based therapy of stroke

H Xin, Y Li, M Chopp - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Cell-based therapy, eg, multipotent mesenchymal stromal cell (MSC) treatment, shows
promise for the treatment of various diseases. The strong paracrine capacity of these cells …

Mesenchymal stem cells and cancer: clinical challenges and opportunities

W Lin, L Huang, Y Li, B Fang, G Li… - BioMed research …, 2019 - Wiley Online Library
Stem cell‐based therapies exhibit profound therapeutic potential for treating various human
diseases, including cancer. Among the cell types that can be used for this purpose …

Microvesicles derived from human bone marrow mesenchymal stem cells inhibit tumor growth

S Bruno, F Collino, MC Deregibus… - Stem cells and …, 2013 - liebertpub.com
Mesenchymal stem cells (MSCs) have opposite effects on tumor growth, being able either to
favor angiogenesis and tumor initiation or to inhibit progression of established tumors …

Potential effect of exosomes derived from cancer stem cells and MSCs on progression of DEN‐induced HCC in rats

FA Alzahrani, MA El-Magd… - Stem Cells …, 2018 - Wiley Online Library
Cross talk, mediated by exosomes, between normal stem cells and cancer stem cells
(CSCs) in the tumor microenvironment has been given less attention so far. In addition, no …

Advances in stem cell therapy for spinal cord injury

AJ Mothe, CH Tator - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
Spinal cord injury (SCI) is a devastating condition producing great personal and societal
costs and for which there is no effective treatment. Stem cell transplantation is a promising …

Conditioned medium from bone marrow-derived mesenchymal stem cells improves recovery after spinal cord injury in rats: an original strategy to avoid cell …

D Cantinieaux, R Quertainmont, S Blacher, L Rossi… - PloS one, 2013 - journals.plos.org
Spinal cord injury triggers irreversible loss of motor and sensory functions. Numerous
strategies aiming at repairing the injured spinal cord have been studied. Among them, the …