The mTOR pathway was discovered in the late 1970s after the compound and natural
inhibitor of mTOR, rapamycin was isolated from the bacterium Streptomyces hygroscopicus …

Ferroptosis, a form of regulated cell death triggered by lipid hydroperoxide accumulation,
has an important role in a variety of diseases and pathological conditions, such as cancer …

Rapamycin and modified rapamycins (rapalogs) have been used to prevent allograft
rejection after organ transplant for over 15 years. The mechanistic target of rapamycin …

The mammalian target of rapamycin (mTOR) critically regulates several essential biological
functions, such as cell growth, metabolism, survival, and immune response by forming two …

MicroRNAs (miRNAs) play a critical role in drug resistance and epithelial-mesenchymal
transition (EMT). The aims of this study were to explore the potential role of miR-206 in …

Stromal cell populations in the tumor microenvironment (TME) play a critical role in the
oncogenesis and metastasis of renal cell carcinoma. In this study, we found that there are α …

Simple Summary Epithelial–mesenchymal transition (EMT) facilitates cell migration,
invasion, and, consequently, metastasis, which ultimately contributes to breast-cancer …

Background: Breast cancer patients who do not respond to neoadjuvant therapy have a poor
prognosis. There is a pressing need for novel targets and models for preclinical testing. Here …

Papillary renal cell carcinoma (pRCC) is the second most common renal cell carcinoma
(RCC) subtype and accounts for 10–15% of all RCCs. Despite clinical need, few …

Background Current chemotherapies for advanced stage metastatic bladder cancer often
result in severe side effects, and most patients become drug resistant over time. Thus, there …