Toll-like receptors: significance, ligands, signaling pathways, and functions in mammals

MK Vidya, VG Kumar, V Sejian, M Bagath… - International reviews …, 2018 - Taylor & Francis
This review attempts to cover the implication of the toll-like receptors (TLRs) in controlling
immune functions with emphasis on their significance, function, regulation and expression …

A comprehensive summary of LL-37, the factotum human cathelicidin peptide

D Vandamme, B Landuyt, W Luyten, L Schoofs - Cellular immunology, 2012 - Elsevier
Cathelicidins are a group of antimicrobial peptides. Since their discovery, it has become
clear that they are an exceptional class of peptides, with some members having pleiotropic …

Vitamin D status in hospitalized patients with SARS-CoV-2 infection

JL Hernández, D Nan… - The Journal of …, 2021 - academic.oup.com
Background The role of vitamin D status in COVID-19 patients is a matter of debate.
Objectives To assess serum 25-hydroxyvitamin D (25OHD) levels in hospitalized patients …

Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans

R Solana, R Tarazona, I Gayoso, O Lesur… - Seminars in …, 2012 - Elsevier
Components of the innate immune response, including neutrophils and macrophages, are
the first line of defense against infections. Their role is to initiate an inflammatory response …

Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19

X Solanich, G Vargas-Parra, CI Van der Made… - Frontiers in …, 2021 - frontiersin.org
Introduction Loss-of-function TLR7 variants have been recently reported in a small number
of males to underlie strong predisposition to severe COVID-19. We aimed to determine the …

Paradoxical changes in innate immunity in aging: recent progress and new directions

RR Montgomery, AC Shaw - Journal of Leucocyte Biology, 2015 - academic.oup.com
Immunosenescence, describing alterations, including decline of immune responses with
age, is comprised of inappropriate elevations, decreases, and dysregulated immune …

Unique features of human cathelicidin LL‐37

K Bandurska, A Berdowska, R Barczyńska‐Felusiak… - Biofactors, 2015 - Wiley Online Library
Cathelicidins are antimicrobial peptides produced by humans and animals in response to
various pathogenic microbes. This review intends to provide a brief overview of the …

Nutrition as personalized medicine against SARS-CoV-2 infections: clinical and oncological options with a specific female groups overview

M Dellino, E Cascardi, M Vinciguerra… - International Journal of …, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) is a respiratory disease caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2). It is acknowledged that vulnerable …

Vitamin D status of Arab Gulf residents screened for SARS-CoV-2 and its association with COVID-19 infection: a multi-centre case–control study

NM Al-Daghri, OE Amer, NH Alotaibi, DA Aldisi… - Journal of translational …, 2021 - Springer
Objectives Vitamin D status in patients with COVID-19 is an on-going controversial issue.
This study aims to determine differences in the serum 25 (OH) D concentrations of Arab Gulf …

Toll-like receptor 8 ligands activate a vitamin D mediated autophagic response that inhibits human immunodeficiency virus type 1

GR Campbell, SA Spector - PLoS pathogens, 2012 - journals.plos.org
Toll-like receptors (TLR) are important in recognizing microbial pathogens and triggering
host innate immune responses, including autophagy, and in the mediation of immune …