The Research Domain Criteria (RDoC) initiative provides a strategy for classifying
psychopathology based on behavioral dimensions and neurobiological measures …

Animal models are useful preclinical tools for studying the pathogenesis of mental disorders
and the effectiveness of their treatment. While it is not possible to mimic all symptoms …

Exposure to stressful events induces depressive-like symptoms and increases susceptibility
to depression. However, the molecular mechanisms are not fully understood. Studies …

Mammals have evolved with a range of innate drives, such as thirst and hunger, that
promote motivated behaviors to ensure survival. A drive for social engagement promotes …

Purpose Although escitalopram is known to be an effective drug for adult depression, its
disease-modifying efficacy on adolescents remains controversial. The present study aimed …

Chronic stress exposure in adolescence can lead to a lasting change in stress
responsiveness later in life and is associated with increased mental health issues in …

More than 80% of depressed patients struggle with learning new tasks, remembering
positive events, or concentrating on a single topic. These neurocognitive deficits …

Background The antidepressant bupropion has received increasing attention as a
pharmacological tool to treat addiction although little is known about its effects on social …

Depression and anxiety are the most common psychiatric disorders, representing a major
public health concern. Dysregulation of oxidative and inflammatory systems may be …

Stress impacts an organism molecularly, physiologically, and behaviourally. It has been
associated with the development of a wide range of physiological and neurological diseases …