The devastating Ebola virus (EBOV) epidemic in West Africa in 2013–2016 accelerated the
progress of several vaccines and antivirals through clinical trials, including the replication …

Background. The magnitude of the 2013–2016 Ebola virus disease outbreak in West Africa
was unprecedented, with> 28 500 reported cases and> 11 000 deaths. Understanding the …

Background The replication-competent recombinant vesicular stomatitis virus (rVSV)–based
vaccine expressing a Zaire ebolavirus (ZEBOV) glycoprotein was selected for rapid safety …

The latest Ebola virus (EBOV) epidemic spread rapidly through Guinea, Sierra Leone, and
Liberia, creating a global public health crisis and accelerating the assessment of …

The filoviruses, Marburg virus and Ebola virus, cause severe hemorrhagic fever with a high
mortality rate in humans and nonhuman primates. Among the most-promising filovirus …

The filoviruses—Ebola virus and Marburg virus—cause lethal haemorrhagic fever in
humans and non-human primates (NHPs). Filoviruses present a global health threat both as …

Most spontaneous DNA double-strand breaks (DSBs) result from replication-fork breakage.
Break-induced replication (BIR), a genome rearrangement–prone repair mechanism that …

Laboratory-acquired infections due to a variety of bacteria, viruses, parasites, and fungi have
been described over the last century, and laboratory workers are at risk of exposure to these …

The folding of monomeric antigens and their subsequent assembly into higher ordered
structures are crucial for robust and effective production of nanoparticle (NP) vaccines in a …

The devastating Ebola virus (EBOV) outbreak in West Africa in 2013–2016 has flagged the
need for the timely development of vaccines for high-threat pathogens. To be better …