Cilia and flagella are ancient, evolutionarily conserved organelles that project from cell
surfaces to perform diverse biological roles, including whole-cell locomotion; movement of …

Centrosomes, which were first described in the late 19th century, are found in most animal
cells and undergo duplication once every cell cycle so that their number remains stable, like …

The centrosome is the primary microtubule organizing center of the cells and templates the
formation of cilia, thereby operating at a nexus of critical cellular functions. Here, we use …

Primary cilium dysfunction underlies the pathogenesis of Bardet-Biedl syndrome (BBS), a
genetic disorder whose symptoms include obesity, retinal degeneration, and nephropathy …

Microtubules and actin filaments are the two main cytoskeleton networks supporting
intracellular architecture and cell polarity. The centrosome nucleates and anchors …

In normal human cells, centrosome loss induced by centrinone—a specific centrosome
duplication inhibitor—leads to irreversible, p53-dependent G1 arrest by an unknown …

Bardet–Biedl syndrome (BBS) is a genetically heterogeneous disorder characterized
primarily by retinal dystrophy, obesity, polydactyly, renal malformations and learning …

Cilia formation is a multi-step process that starts with the docking of a vesicle at the distal
part of the mother centriole. This step marks the conversion of the mother centriole into the …

The protein PCM-1 localizes to cytoplasmic granules known as “centriolar satellites” that are
partly enriched around the centrosome. We inhibited PCM-1 function using a variety of …

Centrosomes of animal cells and spindle pole bodies of fungi are the major microtubule
nucleating centers. Recent studies indicate that their capacity to organize microtubule arrays …