Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Objective The goal of this narrative review is to provide an overview of migraine
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …

The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …

Scientific evidence supports the notion that migraine pathophysiology involves inherited
alteration of brain excitability, intracranial arterial dilatation, recurrent activation, and …

A Systems Neuroscience Approach to Migraine: Neuron Skip to Main Content Advertisement
Neuron This journal offers authors two options (open access or subscription) to publish …

Migraine is a common brain disorder with high disability rates which involves a series of
abnormal neuronal networks, interacting at different levels of the central and peripheral …

Humans have a diverse collection of neuropeptides that can influence a multitude of
activities. There are now over 100 known neuropeptides and probably many more yet to be …

Cluster headache is an excruciating, strictly one-sided pain syndrome with attacks that last
between 15 minutes and 180 minutes and that are accompanied by marked ipsilateral …

Cluster headache is a debilitating primary headache disorder that affects approximately
0.1% of the population worldwide. Cluster headache attacks involve severe unilateral pain …

The management of patients with migraine is often unsatisfactory because available acute
and preventive therapies are either ineffective or poorly tolerated. The acute treatment of …