Recent findings have deeply changed the current view of coronary heart disease, going
beyond the simplistic model of atherosclerosis as a passive process involving cholesterol …

Autonomic nervous system control of the heart is a dynamic process in both health and
disease. A multilevel neural network is responsible for control of chronotropy, lusitropy …

Background: Cardiac sympathetic denervation (CSD) has been shown to reduce the burden
of implantable cardioverter-defibrillator (ICD) shocks in small series of patients with …

Dysfunction of the autonomic nervous system has been implicated in the pathogenesis of
cardiovascular disease, including congestive heart failure and cardiac arrhythmias. Despite …

The autonomic nervous system regulates all aspects of normal cardiac function, and is
recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As …

Neuronal elements distributed throughout the cardiac nervous system, from the level of the
insular cortex to the intrinsic cardiac nervous system, are in constant communication with …

Key points Intrinsic cardiac (IC) neurons undergo differential morphological and phenotypic
remodelling that reflects the site of myocardial infarction (MI). Afferent neural signals from the …

AF is a heterogeneous rhythm disorder that is related to a wide spectrum of etiologies and
has broad clinical presentations. Mechanisms underlying AF are complex and remain …

Ischemic heart disease is the most common cause of lethal ventricular arrhythmias and
sudden cardiac death (SCD). In patients who are at high risk after myocardial infarction …

The cardioprotection afforded by remote ischaemic conditioning (RIC) is mediated via a
complex mechanism involving sensory afferent nerves, the vagus nerve, and release of a …