Non-human primate (NHP) models of Parkinson's disease (PD) have been essential in
understanding the pathophysiology and neural mechanisms underlying PD. The most …

Objective Mounting evidence suggests that α‐synuclein, a major protein component of Lewy
bodies (LB), may be responsible for initiating and spreading the pathological process in …

Dopaminergic denervation in patients with Parkinson's disease is associated with changes
in brain metabolism. Cerebral in-vivo mapping of glucose metabolism has been studied in …

Purpose Although specific positron emission tomography (PET) scanners have been
developed for small animals, spatial resolution remains one of the most critical technical …

Cell transplant therapy for Parkinson's disease (PD) has been in use for over 2 decades as
an experimental treatment. Different cell types have been proposed as better therapeutic …

Background We evaluated the utility of L-3, 4-dihydroxy-6-[18 F] fluoro-phenylalanine ([18 F]
FDOPA) positron emission tomography (PET) as a method for assessing the severity of …

Abstract Carbon-11 labeled dihydrotetrabenazine (11 C-DTBZ) binds to the vesicular
monoamine transporter 2 and has been used to assess nigro-striatal integrity in animal …

Normalization of neuroimaging studies to a stereotaxic space allows the utilization of
standard volumes of interest (VOIs) and voxel-based analysis (SPM). Such spatial …

In this study, we synthesized a new carbon‐11‐labeled radiotracer, 10‐11C‐
dihydrotetrabenazine (10‐11C‐DTBZ), and evaluated its potential as a vesicular …

In the early 1990s, 9-(+)-11C-dihydrotetrabenazine (9-(+)-11C-DTBZ) was shown to be a
useful positron emission tomography (PET) imaging agent for various neurodegenerative …