Vancomycin therapeutic drug monitoring and population pharmacokinetic models in special patient subpopulations

JF Monteiro, SR Hahn, J Gonçalves… - Pharmacology research …, 2018 - Wiley Online Library
Vancomycin is a fundamental antibiotic in the management of severe Gram‐positive
infections. Inappropriate vancomycin dosing is associated with therapeutic failure, bacterial …

[HTML][HTML] Vancomycin dosing nomograms targeting high serum trough levels in different populations: pros and cons

S Elyasi, H Khalili - European journal of clinical pharmacology, 2016 - Springer
Purpose Utilization of higher doses of vancomycin to achieve the trough concentrations of
15–20 mg/L for complicated infections has been recommended by the Infectious Diseases …

[HTML][HTML] AI models to assist vancomycin dosage titration

Z Wang, CLJ Ong, Z Fu - Frontiers in Pharmacology, 2022 - frontiersin.org
Background: Effective treatment using antibiotic vancomycin requires close monitoring of
serum drug levels due to its narrow therapeutic index. In the current practice, physicians use …

[HTML][HTML] A machine learning model that emulates experts' decision making in vancomycin initial dose planning

T Matsuzaki, Y Kato, H Mizoguchi, K Yamada - Journal of Pharmacological …, 2022 - Elsevier
Vancomycin is a glycopeptide antibiotic that is a primary treatment for methicillin-resistant
Staphylococcus aureus infections. To enhance its clinical effectiveness and prevent …

[HTML][HTML] Influences of renal function descriptors on population pharmacokinetic modeling of vancomycin in Chinese adult patients

X Ji, S Ji, X He, X Zhu, R Chen, W Lu - Acta Pharmacologica Sinica, 2018 - nature.com
Vancomycin, a glycopeptide antibiotic for the treatment of grampositive infections, is mainly
eliminated via glomerular filtration. Thus, its therapeutic effects are affected predominantly …

Evaluation of a vancomycin dosing nomogram based on the modification of diet in renal disease equation in intensive care unit patients

BS Golenia, AR Levine, IM Moawad, DD Yeh… - Journal of Critical …, 2013 - Elsevier
Purpose The purpose of the study is to evaluate the effectiveness of a vancomycin
nomogram using actual body weight and the Modification of Diet in Renal Disease equation …

Assessment of appropriateness of an initial dosing regimen of vancomycin and development of a new dosing nomogram

S Yoon, KR Park, SH Lee, SH Song… - Basic & clinical …, 2018 - Wiley Online Library
Vancomycin is a glycopeptide antibiotic used to treat Gram‐positive infections including
methicillin‐resistant Staphylococcus aureus (MRSA). The objectives of this study were to …

Prospective trial of a novel nomogram to achieve updated vancomycin trough concentrations

AR Wesner, ML Brackbill, LL Coyle… - … on Infectious Diseases, 2013 - Wiley Online Library
Purpose. To determine if the use of a novel vancomycin nomogram predicts dosing
regimens that achieve target trough concentrations equal to or more accurate than dosing …

[HTML][HTML] Elevated vancomycin trough concentration: increased efficacy and/or toxicity?

S Elyasi, H Khalili, S Dashti-Khavidaki… - Iranian Journal of …, 2014 - ncbi.nlm.nih.gov
Vancomycin susceptibility of methicillin-resistant Staphylococcus aureus has been changed
over time and its average minimum inhibitory concentration increased from 1.5 to 1.75 …

Initial dosing of intermittent vancomycin in adults: estimation of dosing interval in relation to dose and renal function

M Šíma, J Hartinger, T Grus, O Slanař - European Journal of Hospital …, 2021 - ejhp.bmj.com
Objectives Due to the high interindividual variability in vancomycin pharmacokinetics,
optimisation of its dosing is still challenging. This study aimed to explore vancomycin …