Epithelial–mesenchymal transition (EMT) is a process in which epithelial cells acquire
mesenchymal features. In cancer, EMT is associated with tumor initiation, invasion …

Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

Gliomas are the most common tumours of the central nervous system and the most
aggressive form is glioblastoma (GBM). Despite advances in treatment, patient survival …

The release of circulating tumor cells (CTCs) into vasculature is an early event in the
metastatic process. The analysis of CTCs in patients has recently received widespread …

Current algorithms for the clinical management of patients with squamous cell carcinoma of
the head and neck (HNSCC) are based on a stage-dependent strategy where all patients at …

Cancer remains the leading cause of death worldwide despite the enormous efforts that are
made in the development of cancer biology and anticancer therapeutic treatment …

Oral cancer is one of the most prevalent forms of cancer worldwide. Carcinogenesis is a
complex process, in which heterogeneity plays an important role in the development and …

Tumor biopsy is the gold standard for the assessment of clinical biomarkers for treatment.
However, tumors change dynamically in response to therapy, and there remains a need for …

Head and Neck cancers (HNC) are a heterogeneous group of upper aero-digestive tract
cancer and account for 931,922 new cases and 467,125 deaths worldwide. About 90% of …

Circulating tumour cells (CTCs) are the metastatic precursors to distant disease in head and
neck cancers (HNCs). Whilst the prognostic and predictive value of single CTCs have been …