Plasmodium sporozoites are the product of a complex developmental process in the
mosquito vector and are destined to infect the mammalian liver. Attention has been drawn to …

RTS, S is the most advanced candidate vaccine against human malaria. During its
remarkable journey from conception and design in the early 1980s to the multicenter Phase …

Plasmodium sporozoites make a remarkable journey from the mosquito midgut to the
mammalian liver. The sporozoite's major surface protein, circumsporozoite protein (CSP), is …

The liver stages of malaria are clinically silent but have a central role in the Plasmodium life
cycle. Liver stages of the parasite containing thousands of merozoites grow inside …

The incidence of malaria is increasing, and there is an urgent need to identify new drug
targets for both prophylaxis and chemotherapy. Potential new drug targets include …

Plasmodium spp. undergo a complex obligate developmental cycle within their invertebrate
vectors that enables transmission between vertebrate hosts. This developmental cycle …

▪ Abstract Plasmodium sporozoites display complex phenotypes including gliding motility
and invasion of and transmigration through cells in the mosquito vector and the vertebrate …

Erythrocytic stages of the malaria parasite Plasmodium falciparum express four related
papain-family cysteine proteases, termed falcipains. Falcipain-2 and falcipain-3 are food …

Malaria is one of the deadliest diseases. Because of the ineffectiveness of current malaria-
control methods, several novel mosquito vector-based control strategies have been …

SM1 is a twelve-amino-acid peptide that binds tightly to the Anopheles salivary gland and
inhibits its invasion by Plasmodium sporozoites. By use of UV-crosslinking experiments …