Eosinophils from physiology to disease: a comprehensive review

GA Ramirez, MR Yacoub, M Ripa… - BioMed research …, 2018 - Wiley Online Library
Despite being the second least represented granulocyte subpopulation in the circulating
blood, eosinophils are receiving a growing interest from the scientific community, due to their …

The multidisciplinary approach to eosinophilia

GN Thomsen, MN Christoffersen… - Frontiers in …, 2023 - frontiersin.org
Eosinophilic granulocytes are normally present in low numbers in the bloodstream. Patients
with an increased number of eosinophilic granulocytes in the differential count (eosinophilia) …

Targeted next-generation sequencing identifies a subset of idiopathic hypereosinophilic syndrome with features similar to chronic eosinophilic leukemia, not otherwise …

SA Wang, W Tam, AG Tsai, DA Arber… - Modern …, 2016 - nature.com
The distinction between chronic eosinophilic leukemia, not otherwise specified and
idiopathic hypereosinophilic syndrome largely relies on clonality assessment. Prior to the …

[HTML][HTML] Bone marrow morphology is a strong discriminator between chronic eosinophilic leukemia, not otherwise specified and reactive idiopathic hypereosinophilic …

SA Wang, RP Hasserjian, W Tam, AG Tsai… - …, 2017 - ncbi.nlm.nih.gov
Chronic eosinophilic leukemia, not otherwise specified can be difficult to distinguish from
idiopathic hypereosinophilic syndrome according to the current World Health Organization …

Revisiting the NIH taskforce on the research needs of eosinophil-associated diseases (RE-TREAD)

P Khoury, P Akuthota, SJ Ackerman… - Journal of leukocyte …, 2018 - academic.oup.com
Eosinophil-associated diseases (EADs) are rare, heterogeneous disorders characterized by
the presence of eosinophils in tissues and/or peripheral blood resulting in …

Idiopathic hypereosinophilia is clonal disorder? Clonality identified by targeted sequencing

JS Lee, H Seo, K Im, SN Park, SM Kim, EK Lee… - PLoS …, 2017 - journals.plos.org
Idiopathic hypereosinophilia (IHE)/idiopathic hypereosinophilic syndrome (IHES) has been
defined by a persistent elevation of the blood eosinophil count exceeding 1.5× 103/μL …

Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations

HM Nielsen, CL Andersen, M Westman… - Scientific Reports, 2017 - nature.com
This is the first study to compare genome-wide DNA methylation profiles of sorted blood
cells from myelofibrosis (MF) patients and healthy controls. We found that differentially …

Hypereosinophilic syndrome in the differential diagnosis of pulmonary infiltrates with eosinophilia

N Zimmermann, KA Wikenheiser-Brokamp - Annals of Allergy, Asthma & …, 2018 - Elsevier
Objective To describe key diagnostic considerations in patients with pulmonary infiltrates
with eosinophilia, with a special emphasis on raising awareness of hypereosinophilic …

Myeloid neoplasm with a novel cryptic PDGFRB rearrangement detected by next-generation sequencing

N Zimmermann, M Nassiri, J Zhou, AM Miller, S Zhang - Cancer Genetics, 2020 - Elsevier
Rearrangements of PDGFRB are defining cytogenetic abnormalities seen in
“Myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRB” and are …

Developing a standardized approach for assessing mast cells and eosinophils on tissue biopsies: a work group report of the AAAAI allergic skin diseases committee

N Zimmermann, JP Abonia, SC Dreskin, C Akin… - Journal of Allergy and …, 2021 - Elsevier
Mast cells and eosinophils are commonly found, expectedly or unexpectedly, in human
tissue biopsies. Although the clinical significance of their presence, absence, quantity, and …