Physical models of collective cell migration

R Alert, X Trepat - Annual Review of Condensed Matter Physics, 2020 - annualreviews.org
Collective cell migration is a key driver of embryonic development, wound healing, and
some types of cancer invasion. Here, we provide a physical perspective of the mechanisms …

Multi-scale nature of the tissue surface tension: Theoretical consideration on tissue model systems

I Pajic-Lijakovic, R Eftimie, M Milivojevic… - Advances in Colloid and …, 2023 - Elsevier
Tissue surface tension is one of the key parameters that govern tissue rearrangement,
shaping, and segregation within various compartments during organogenesis, wound …

Bridging from single to collective cell migration: A review of models and links to experiments

A Buttenschön, L Edelstein-Keshet - PLoS computational biology, 2020 - journals.plos.org
Mathematical and computational models can assist in gaining an understanding of cell
behavior at many levels of organization. Here, we review models in the literature that focus …

Dynamic migration modes of collective cells

SZ Lin, S Ye, GK Xu, B Li, XQ Feng - Biophysical journal, 2018 - cell.com
Collective cell migration occurs in a diversity of physiological processes such as wound
healing, cancer metastasis, and embryonic morphogenesis. In the collective context …

Derivation and simulation of a computational model of active cell populations: How overlap avoidance, deformability, cell-cell junctions and cytoskeletal forces affect …

V Leech, FN Kenny, S Marcotti, TJ Shaw… - PLOS Computational …, 2024 - journals.plos.org
Collective alignment of cell populations is a commonly observed phenomena in biology. An
important example are aligning fibroblasts in healthy or scar tissue. In this work we derive …

Tractions and stress fibers control cell shape and rearrangements in collective cell migration

A Saraswathibhatla, J Notbohm - Physical Review X, 2020 - APS
Key to collective cell migration is the ability of cells to rearrange their position with respect to
their neighbors. Recent theory and experiments demonstrate that cellular rearrangements …

[PDF][PDF] Cellular mechanics of wound formation in single cell layer under cyclic stretching

J Xu, X Xu, X Li, S He, D Li, B Ji - Biophysical Journal, 2022 - cell.com
Wounds can be produced when cells and tissues are subjected to excessive forces, for
instance, under pathological conditions or nonphysiological loading. However, the cellular …

Vertex model with internal dissipation enables sustained flows

J Rozman, KVS Chaithanya, JM Yeomans… - Nature …, 2025 - nature.com
Complex tissue flows in epithelia are driven by intra-and inter-cellular processes that
generate, maintain, and coordinate mechanical forces. There has been growing evidence …

Viscoelasticity and cell jamming state transition

I Pajic-Lijakovic, M Milivojevic - The European Physical Journal Plus, 2021 - Springer
Although collective cell migration (CCM) is a highly coordinated migratory mode,
perturbations in the form of jamming state transitions and vice versa often occur even in 2D …

Epithelial cell-cell interactions in an overcrowded environment: jamming or live cell extrusion

I Pajic-Lijakovic, M Milivojevic… - Journal of Biological …, 2024 - Springer
Epithelial tissues respond strongly to the mechanical stress caused by collective cell
migration and are able to regulate it, which is important for biological processes such as …