In the 20th century, researchers studying animal and plant signaling pathways discovered a
protein domain that is shared across diverse innate immune systems: the Toll/interleukin …

Abstract Charcot‐Marie‐Tooth (CMT) neuropathies are one of the most common
neuromuscular disorders. However, despite the identification of more than 100 causative …

Background In response to injury, neurons activate a program of organized axon self-
destruction initiated by the NAD+ hydrolase, SARM1. In healthy neurons SARM1 is …

Charcot-Marie-Tooth disease type 2A (CMT2A) is an axonal neuropathy caused by
mutations in the mitofusin 2 (MFN2) gene. MFN2 mutations result in profound mitochondrial …

Wallerian axonal degeneration (WD) does not occur in the nematode C. elegans, in contrast
to other model animals. However, WD depends on the NADase activity of SARM1, a protein …

Brain cancer and leukemia are the most common cancers diagnosed in the pediatric
population and are often treated with lifesaving chemotherapy. However, chemotherapy …

Axons are an essential component of the nervous system, and axon degeneration is an
early feature of many neurodegenerative disorders. The NAD+ metabolome plays an …

Sterile alpha and TIR motif-containing 1 (SARM1) is a protein involved in programmed death
of injured axons. Following axon injury or a drug-induced insult, the TIR domain of SARM1 …

Axon loss contributes to many common neurodegenerative disorders. In healthy axons, the
axon survival factor NMNAT2 inhibits SARM1, the central executioner of programmed axon …

Axons are considered to be particularly vulnerable components of the nervous system;
impairments to a neuron's axon leads to an effective silencing of a neuron's ability to …