Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move
along the surface of, or destabilize, microtubule filaments. Much progress has been made in …

The strategy of clinically targeting cancerous cells at their most vulnerable state during
mitosis has instigated numerous studies into the mitotic cell death (MCD) pathway. As the …

Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …

Withaferin A (WFA) is purified from the plant Withania somnifera and inhibits the vimentin
cytoskeleton. Vimentin overexpression in cancer correlates with metastatic disease …

Cell cycle deregulation is a common feature of human cancer. Tumor cells accumulate
mutations that result in unscheduled proliferation, genomic instability and chromosomal …

The process of mitosis is a validated point of intervention in cancer therapy and a variety of
anti-mitotic drugs are successfully being used in the clinic. To date, all approved antimitotics …

The kinesin superfamily (KIF) is a group of proteins that share a highly conserved motor
domain. Except for some members, many KIF proteins have adenosine triphosphatase …

The kinesin superfamily contains a conserved class of microtubule‐dependent molecular
motor proteins that possess an adenosine triphosphatase activity and motion characteristics …

Chromosome alignment and biorientation is essential for mitotic progression and genomic
stability. Most chromosomes align at the spindle equator in a motor-independent manner …

Mutations in cancer cells frequently result in cell cycle alterations that lead to unrestricted
growth compared to normal cells. Considering this phenomenon, many drugs have been …