Abstract The E2 factor (E2F) family of transcription factors are downstream targets of the
retinoblastoma protein. E2F factors have been known for several years to be important …

The E2F transcription factors are key regulators of cell cycle progression and the E2F field
has made rapid advances since its advent in 1986. Yet, while our understanding of the roles …

Motivation: Understanding the full meaning of the biology captured in molecular profiles,
within the context of the entire biological system, cannot be achieved with a simple …

The E2F transcription factors are critical regulators of genes required for appropriate
progression through the cell cycle, and in special circumstances they can also promote the …

Exposure to genotoxic agents is a major cause of human cancer, and cellular responses to
genotoxic stress are important defense mechanisms. These responses are very complex …

The retinoblastoma (RB) tumor suppressor is known as a master regulator of the cell cycle.
RB is mutated or functionally inactivated in the majority of human cancers. This …

E2F is a family of transcription factors that regulate the expression of genes involved in a
wide range of cellular processes, including cell-cycle progression, DNA replication, DNA …

BRCA1 C-terminal (BRCT) domains are integral signaling modules in the DNA damage
response (DDR). Aside from their established roles as phospho-peptide binding modules …

Protein phosphorylation by protein kinases may generate docking sites for other proteins. It
thus allows the assembly of signaling complexes in response to kinase activation. Several …

The E2F1 transcription factor is a recognized regulator of the cell cycle as well as a potent
mediator of DNA damage-induced apoptosis and the checkpoint response. Understanding …