Viral vectors in gene therapy: Where do we stand in 2023?

K Lundstrom - Viruses, 2023 - mdpi.com
Viral vectors have been used for a broad spectrum of gene therapy for both acute and
chronic diseases. In the context of cancer gene therapy, viral vectors expressing anti-tumor …

Primary open-angle glaucoma

RN Weinreb, CKS Leung, JG Crowston… - Nature reviews Disease …, 2016 - nature.com
Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …

The molecular basis of retinal ganglion cell death in glaucoma

M Almasieh, AM Wilson, B Morquette… - Progress in retinal and …, 2012 - Elsevier
Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases

N Cuenca, L Fernández-Sánchez, L Campello… - Progress in retinal and …, 2014 - Elsevier
Retinal neurodegenerative diseases like age-related macular degeneration, glaucoma,
diabetic retinopathy and retinitis pigmentosa each have a different etiology and …

[HTML][HTML] Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration

A Bi, J Cui, YP Ma, E Olshevskaya, M Pu, AM Dizhoor… - Neuron, 2006 - cell.com
The death of photoreceptor cells caused by retinal degenerative diseases often results in a
complete loss of retinal responses to light. We explore the feasibility of converting inner …

Inducible rodent models of glaucoma

IH Pang, AF Clark - Progress in retinal and eye research, 2020 - Elsevier
Glaucoma is one of the leading causes of vision impairment worldwide. In order to further
understand the molecular pathobiology of this disease and to develop better therapies …

Neuroprotection, growth factors and BDNF-TrkB signalling in retinal degeneration

A Kimura, K Namekata, X Guo, C Harada… - International journal of …, 2016 - mdpi.com
Neurotrophic factors play key roles in the development and survival of neurons. The potent
neuroprotective effects of neurotrophic factors, including brain-derived neurotrophic factor …

Neuroprotection of retinal ganglion cells by a novel gene therapy construct that achieves sustained enhancement of brain-derived neurotrophic factor/tropomyosin …

A Osborne, TZ Khatib, L Songra, AC Barber… - Cell Death & …, 2018 - nature.com
Previous studies have demonstrated that intravitreal delivery of brain-derived neurotrophic
factor (BDNF) by injection of recombinant protein or by gene therapy can alleviate retinal …

[HTML][HTML] Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma

TV Johnson, ND Bull, DP Hunt, N Marina… - … & visual science, 2010 - arvojournals.org
Purpose.: Retrograde neurotrophic factor transport blockade has been implicated in the
pathophysiology of glaucoma. Stem cell transplantation appears to ameliorate some …

[HTML][HTML] Focus: microbiome: human microbiota and ophthalmic disease

LJ Lu, J Liu - The Yale journal of biology and medicine, 2016 - ncbi.nlm.nih.gov
The human ocular surface, consisting of the cornea and conjunctiva, is colonized by an
expansive, diverse microbial community. Molecular-based methods, such as 16S rRNA …