Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …

NMDA receptors (NMDARs) are glutamate-gated ion channels and are crucial for neuronal
communication. NMDARs form tetrameric complexes that consist of several homologous …

Epilepsy is one of the most common neurological disorders, yet its pathophysiology is poorly
understood due to the high complexity of affected neuronal circuits. To identify dysfunctional …

In spike-timing-dependent plasticity (STDP), the order and precise temporal interval
between presynaptic and postsynaptic spikes determine the sign and magnitude of long …

Glutamate is the primary excitatory neurotransmitter in mammalian brain. Disturbances in
glutamate-mediated neurotransmission have been increasingly documented in a range of …

The occurrence of cognitive disturbances upon CNS inflammation or infection has been
correlated with increased levels of the cytokine tumor necrosis factor-α (TNFα). To date …

Beyond their well-established role as triggers for LTP and LTD of fast synaptic transmission
mediated by AMPA receptors, an expanding body of evidence indicates that NMDA …

Endocannabinoid mediated spike timing–dependent depression (t-LTD) is crucially involved
in the development of the sensory neocortex. t-LTD at excitatory synapses in the developing …

Synaptic plasticity confers environmental adaptability through modification of the
connectivity between neurons and neuronal circuits. This is achieved through changes to …