EG Foerster, T Mukherjee, L Cabral-Fernandes… - Autophagy, 2022 - Taylor & Francis
Macroautophagy/autophagy is a cellular catabolic process that results in lysosome- mediated recycling of organelles and protein aggregates, as well as the destruction of …
S Xu, X Li, S Zhang, C Qi, Z Zhang, R Ma, L Xiang… - BMC medicine, 2023 - Springer
Background Oxidative stress (OS) is a key pathophysiological mechanism in Crohn's disease (CD). OS-related genes can be affected by environmental factors, intestinal …
Genome-wide association studies (GWASs) have identified hundreds of loci associated with Crohn's disease (CD). However, as with all complex diseases, robust identification of the …
NM Martinez, A Su, MC Burns, JK Nussbacher… - Molecular cell, 2022 - cell.com
Pseudouridine is a modified nucleotide that is prevalent in human mRNAs and is dynamically regulated. Here, we investigate when in their life cycle mRNAs become …
The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …
Abstract Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases in high- income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …
A general consensus exists that IBD is associated with compositional and metabolic changes in the intestinal microbiota (dysbiosis). However, a direct causal relationship …
Key challenges for human genetics, precision medicine and evolutionary biology include deciphering the regulatory code of gene expression and understanding the transcriptional …