Depression, a complex psychiatric disorder that affects∼ 15% of the population, has an
enormous social cost. Although the disorder is thought to be the outcome of gene …

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are of fundamental
importance in the brain. They are responsible for the majority of fast excitatory synaptic …

Homeostatic synaptic scaling alters the strength of synapses to compensate for prolonged
changes in network activity and involves both excitatory and inhibitory neurons. The …

Major antidepressant agents increase synaptic levels of monoamines. Although the
monoamine hypothesis of depression remains a cornerstone of our understanding of the …

Neuronal activity regulated pentraxin (Narp) has been implicated in the aggregation of
AMPA-type glutamate receptors (GluR) at excitatory synapses. In the present paper, we …

Recent studies have provided compelling evidence demonstrating that orexin (also known
as hypocretin) neurons play a central role in the pathophysiology of narcolepsy. However …

Perinatal hypoxia–ischemia (HI) is the most common cause of cerebral palsy, and an
important consequence of perinatal HI is epilepsy. Epilepsy is a disorder in which the …

Perinatal hypoxia-ischemia (HI) is the most common cause of various neurological
disabilities in children with high societal cost. Hypoxic-ischemic brain damage is an evolving …

Anxiety disorders significantly impair quality of life. However, limited knowledge of the
underlying mechanisms impedes the development of effective therapeutics. Previous …

Schizophrenia (SCZ) is a severe psychiatric disorder with a genetic susceptibility. Alterations
in neurochemical signaling, as well as changes in brain structure and function, manifest …