Understanding the mechanisms underlying autism spectrum disorders (ASDs) is a
challenging goal. Here we review recent progress on several fronts, including genetics …

Researchers have now identified many highly penetrant genetic risk factors for autism
spectrum disorder (ASD). Some of these genes encode synaptic proteins, lending support to …

Development of the human nervous system involves complex interactions among
fundamental cellular processes and requires a multitude of genes, many of which remain to …

Neurodevelopmental disorders (NDDs) affect more than 3% of children and are attributable
to single-gene mutations at more than 1000 loci. Traditional methods yield molecular …

Autism spectrum disorder (ASD) includes a set of highly heritable neurodevelopmental
syndromes characterized by social and communication impairment, repetitive behaviour …

Cell identity is tightly controlled by specific transcriptional programs which require post-
translational modifications of histones. These histone modifications allow the establishment …

De novo truncating mutations in Additional sex combs-like 3 (ASXL3) have been identified in
individuals with Bainbridge–Ropers syndrome (BRS), characterized by failure to thrive …

Additional sex combs-like (ASXL) proteins are mammalian homologs of Addition of sex
combs (Asx), a protein that regulates the balance of trithorax and Polycomb function in …

Congenital microcephaly (CM) exhibits broad clinical and genetic heterogeneity and is thus
categorized into several subtypes. However, the recent bloom of disease–gene discoveries …

Background Bainbridge-Ropers syndrome (BRPS) is a recently described developmental
disorder caused by de novo truncating mutations in the additional sex combs like 3 (ASXL3) …