Over the past few decades the extent to which cytotoxic T lymphocytes (CTLs) control human
immunodeficiency virus (HIV) replication has been studied extensively, yet their role and …

Biological sex differences affect the course of HIV infection, with untreated women having
lower viral loads compared to their male counterparts but, for a given viral load, women have …

A severe bottleneck exists during HIV-1 mucosal transmission. However, viral properties that
determine HIV-1 transmissibility are not fully elucidated. We identified multiple …

Background Fitness costs and slower disease progression are associated with a cytolytic T
lymphocyte (CTL) escape mutation T242N in Gag in HIV-1-infected individuals carrying HLA …

Objective Viral fitness plays an important role in HIV-1 evolution, transmission and
pathogenesis. However, how mutations accumulated during early infection affect viral fitness …

While prior studies have demonstrated that CD8 T cell responses to cryptic epitopes (CE)
are readily detectable during HIV-1 infection, their ability to drive escape mutations following …

The suppression of viral loads and identification of selection signatures in non-human
primates after challenge are indicators for effective human immunodeficiency virus …

HIV-1 以其庞大的基因多样性及快速的变异能力, 不断地逃逸人类免疫系统的监控, 至今为止,
尚未研发出有效的疫苗和治愈方法. 研究HIV-1 的进化模式及其与人类免疫系统之间的“博弈” …

Background Mutations rapidly accumulate in the HIV-1 genome after infection. Some of
those mutations are selected by host immune responses and often cause viral fitness losses …

After nearly four decades of scientific research, a global solution in eradicating the human
immunodeficiency virus-1 (HIV-1) pandemic has still yet to be discovered. The advent of …