The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …

Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …

The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …

Low-protein diets promote metabolic health in rodents and humans, and the benefits of low-
protein diets are recapitulated by specifically reducing dietary levels of the three branched …

The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …

Cellular metabolism is at the foundation of all biological activities. The catabolic processes
that support cellular bioenergetics and survival have been well studied. By contrast, how …

The highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally
known as mammalian target of rapamycin) is a central cell growth regulator connecting …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

The maintenance of organismal homeostasis requires partitioning and transport of
biochemical molecules between organ systems, their composite cells, and subcellular …

The postprandial rise in essential amino acid (EAA) concentrations modulates the increase
in muscle protein synthesis rates after protein ingestion. The EAA content and AA …