Using autopsies to dissect COVID-19 pathogenesis

F Heinrich, KD Mertz, M Glatzel, M Beer… - Nature …, 2023 - nature.com
The emergence of SARS-CoV-2 has resulted in millions of deaths as a result of COVID-19.
Suitable models were missing at the beginning of the pandemic, and studies investigating …

Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients

M Khan, M Clijsters, S Choi, W Backaert, M Claerhout… - Neuron, 2022 - cell.com
Can SARS-CoV-2 hitchhike on the olfactory projection and take a direct and short route from
the nose into the brain? We reasoned that the neurotropic or neuroinvasive capacity of the …

Thromboinflammation in COVID-19: Unraveling the interplay of coagulation and inflammation

EI Obeagu, GU Obeagu - Medicine, 2024 - journals.lww.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has not only challenged
global health systems but also spurred intense scientific inquiry into its pathophysiology …

Microvascular thrombosis as a critical factor in severe COVID-19

PP Wadowski, B Panzer, A Józkowicz… - International Journal of …, 2023 - mdpi.com
Platelet–endothelial interactions have a critical role in microcirculatory function, which
maintains tissue homeostasis. The subtle equilibrium between platelets and the vessel wall …

The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling

M Ackermann, JC Kamp, C Werlein, CL Walsh… - …, 2022 - thelancet.com
Background COVID-19 is characterized by a heterogeneous clinical presentation, ranging
from mild symptoms to severe courses of disease. 9–20% of hospitalized patients with …

Neuropathological features of SARS-CoV-2 delta and omicron variants

E Normandin, N Valizadeh, EA Rudmann… - … of Neuropathology & …, 2023 - academic.oup.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continually evolving
resulting in variants with increased transmissibility, more severe disease, reduced …

Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues

CE Nelson, S Namasivayam, TW Foreman… - Science …, 2022 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily replicates in
mucosal sites, and more information is needed about immune responses in infected tissues …

The stereotypic response of the pulmonary vasculature to respiratory viral infections: Findings in mouse models of SARS-CoV-2, influenza A and gammaherpesvirus …

S De Neck, R Penrice-Randal, JJ Clark, P Sharma… - Viruses, 2023 - mdpi.com
The respiratory system is the main target of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), the cause of coronavirus disease 19 (COVID-19) where acute respiratory …

Heparin, low molecular weight heparin, and non-anticoagulant derivatives for the treatment of inflammatory lung disease

JK Shute - Pharmaceuticals, 2023 - mdpi.com
Unfractionated heparin has multiple pharmacological activities beyond anticoagulation.
These anti-inflammatory, anti-microbial, and mucoactive activities are shared in part by low …

[HTML][HTML] Improving neuropsychological rehabilitation for COVID-19 patients

CN Widmann, J Kolano… - Zeitschrift für …, 2023 - econtent.hogrefe.com
Cognitive sequelae after recovery from an initial COVID-19 disease are present in a subset
of affected individuals, coalescing around several important issues such as effects of age …