Ovarian cancer (OC) is one of the most common types of cancer in women with a high
mortality rate, and the treatment of OC is prone to high recurrence rates and side effects …

The cell painting (CP) assay has emerged as a potent imaging-based high-throughput
phenotypic profiling (HTPP) tool that provides comprehensive input data for in silico …

Prolonged obstruction of the ureter, which leads to injury of the kidney collecting ducts,
results in permanent structural damage, while early reversal allows for repair. Cell structure …

Centromeres, where the kinetochore complex binds, are susceptible to damages including
DNA double-stranded breaks (DSBs). Here, we report the functional significance and the …

Cell cycle-dependent gene expression analysis is particularly important as numerous genes
show tightly regulated expression patterns at different phases of the cell cycle. For cancer …

Cancer is the second leading cause of death worldwide after heart disease. The current
treatment options to fight cancer are limited, and there is a critical need for better treatment …

Summary Inosine monophosphate dehydrogenase 2 (IMPDH2) is highly expressed in
human cancers; however, its physiological relevance under growth signaling remains to be …

Transcription takes place over a significant portion of the human genome. However, only a
small portion of the transcriptome, roughly 1.2%, consists of RNAs translated into proteins; …

[ES] El cáncer es un grupo heterogéneo de enfermedades cuya incidencia está en aumento
y el cual se espera que constituya la principal causa de muerte del siglo XXI. El cáncer de …

DONSON is a novel replisome and replication fork stabilisation factor that is essential for
efficient DNA replication and is particularly important during times of increased replicative …