TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human
cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 …

Antisense technology is now beginning to deliver on its promise to treat diseases by
targeting RNA. Nine single-stranded antisense oligonucleotide (ASO) drugs representing …

Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

MicroRNAs (miRNAs) are 20–24 nucleotide noncoding RNAs abundant in plants and
animals. The biogenesis of plant miRNAs involves transcription of miRNA genes, processing …

Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from
anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag …

Abstract Background N6-methyladenosine (m 6 A) modification is known to impact many
aspects of RNA metabolism, including mRNA stability and translation, and is highly …

MicroRNAs (miRNAs) are important regulators of gene expression that bind complementary
target mRNAs and repress their expression. Precursor miRNA molecules undergo nuclear …

Abstract Background Circular RNAs (circRNAs) play important regulatory roles in multiple
human malignancies, including non-small cell lung cancer (NSCLC). Here, we explored the …

The advent of ribosome profiling and other tools to probe mRNA translation has revealed
that codon bias—the uneven use of synonymous codons in the transcriptome—serves as a …

Background Trichomes play a key role in the development of plants and exist in a wide
variety of species. Results In this paper, it was reviewed that the structure and morphology …