Chronic myeloid leukemia (CML) is probably the most extensively studied human
malignancy. The discovery of the Philadelphia (Ph) chromosome in 19601 as the first …

Once engaged by soluble or matrix-anchored ligands, cell surface proteins are commonly
sorted to lysosomal degradation through several endocytic pathways. Defective vesicular …

Receptor desensitization is accomplished by accelerated endocytosis and degradation of
ligand–receptor complexes. An in vitro reconstituted system indicates that Cbl adaptor …

Ubiquitin-protein ligases (E3s) regulate diverse cellular processes by mediating protein
ubiquitination. The c-Cbl proto-oncogene is a RING family E3 that recognizes activated …

CBL encodes a member of the Cbl family of proteins, which functions as an E3 ubiquitin
ligase. We describe a dominant developmental disorder resulting from germline missense …

Ubiquitination of receptor protein-tyrosine kinases (RPTKs) terminates signaling by marking
active receptors for degradation. c-Cbl, an adapter protein for RPTKs, positively regulates …

The ubiquitin‐proteasome pathway has emerged as a central player in the regulation of
several diverse cellular processes. Here, we describe the important components of this …

Responses to extracellular stimuli are often transduced from cell-surface receptors to protein
tyrosine kinases which, when activated, initiate the formation of protein complexes that …

In the past 18 months, two RING finger structures have been solved. They represent the first
reported structures for this novel zinc-binding sequence motif. Both structures are …

The c-Abl tyrosine kinase localizes to the cytoplasm and plasma membrane in addition to
the nucleus. However, there is little information regarding a role for c-Abl in the …