Lactobacillus rhamnosus GG (LGG) was the first strain belonging to the genus Lactobacillus
to be patented in 1989 thanks to its ability to survive and to proliferate at gastric acid pH and …

Abstract Serotonin (5-HT) has been recognized for decades as an important signalling
molecule in the gut, but it is still revealing its secrets. Novel gastrointestinal functions of 5-HT …

Functional constipation (FC), a condition characterized by heterogeneous symptoms
(infrequent bowel movements, hard stools, excessive straining, or a sense of incomplete …

5-Hydroxytryptamine (serotonin) in the gastrointestinal trac... : Current Opinion in
Endocrinology, Diabetes and Obesity 5-Hydroxytryptamine (serotonin) in the …

Background & Aims Increased colonic serotonin (5-HT) level and decreased serotonin
reuptake transporter (SERT) expression in irritable bowel syndrome (IBS) may contribute to …

The gastrointestinal tract contains its own set of intrinsic neuroglial circuits—the enteric
nervous system (ENS)—which detects and responds to diverse signals from the …

Irritable bowel syndrome (IBS) remains a clinical challenge in the 21 st century. It's the most
commonly diagnosed gastrointestinal condition and also the most common reason for …

Background Irritable bowel syndrome with diarrhoea (IBS-D) is particularly debilitating due
to urgency and episodic incontinence. Some 5-hydroxytryptamine 3 (5-HT3) receptor …

The acute phase of IBD with inflamed gut and often ulcerated mucosa is clearly different
from the apparently normal mucosa characteristic of IBS. However, more detailed …

Background Irritable bowel syndrome (IBS), one of the most common gastrointestinal
disorders, markedly impairing patients' quality of life. Drug development for IBS treatment …