Understanding COVID-19 in children: immune determinants and post-infection conditions

GA Rotulo, P Palma - Pediatric research, 2023 - nature.com
Coronavirus disease 2019 in children presents with milder clinical manifestations than in
adults. On the other hand, the presence of a wide range of inflammatory manifestations …

Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C

J Tang, T Novak, J Hecker, G Grubbs, FT Zahra… - Nature …, 2022 - nature.com
Neutralization capacity of antibodies against Omicron after a prior SARS-CoV-2 infection in
children and adolescents is not well studied. Therefore, we evaluated virus-neutralizing …

Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine

Y Feng, M Yuan, JM Powers, M Hu, JE Munt… - Science translational …, 2023 - science.org
The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants that evade immunity elicited by vaccination has placed an imperative on the …

Antibody affinity and cross-variant neutralization of SARS-CoV-2 Omicron BA. 1, BA. 2 and BA. 3 following third mRNA vaccination

L Bellusci, G Grubbs, FT Zahra, D Forgacs… - Nature …, 2022 - nature.com
There is limited knowledge on durability of neutralization capacity and antibody affinity
maturation generated following two versus three doses of SARS-CoV-2 mRNA vaccines in …

[HTML][HTML] Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth

F Wimmers, AR Burrell, Y Feng, H Zheng… - Cell, 2023 - cell.com
The dynamics of immunity to infection in infants remain obscure. Here, we used a multi-
omics approach to perform a longitudinal analysis of immunity to severe acute respiratory …

The role of immunity in the pathogenesis of SARS-CoV-2 infection and in the protection generated by COVID-19 vaccines in different age groups

ZA Abdulla, SM Al-Bashir, H Alzoubi, NS Al-Salih… - Pathogens, 2023 - mdpi.com
This study aims to review the available data regarding the central role of immunity in
combating SARS-CoV-2 infection and in the generation of protection by vaccination against …

SARS-CoV-2 accessory proteins reveal distinct serological signatures in children

A Hachim, H Gu, O Kavian, M Mori, MYW Kwan… - Nature …, 2022 - nature.com
The antibody response magnitude and kinetics may impact clinical severity, serological
diagnosis and long-term protection of COVID-19, which may play a role in why children …

SARS-CoV-2 infection and recovery in children: Distinct T cell responses in MIS-C compared to COVID-19

K Rybkina, JN Bell, MC Bradley, T Wohlbold… - Journal of Experimental …, 2023 - rupress.org
SARS-CoV-2 infection for most children results in mild or minimal symptoms, though in rare
cases severe disease can develop, including a multisystem inflammatory syndrome (MIS-C) …

Neutrophil profiles of pediatric COVID-19 and multisystem inflammatory syndrome in children

BP Boribong, TJ LaSalle, YC Bartsch, F Ellett… - Cell Reports …, 2022 - cell.com
Multisystem inflammatory syndrome in children (MIS-C) is a delayed-onset, COVID-19-
related hyperinflammatory illness characterized by severe acute respiratory syndrome …

Multiplatform analyses reveal distinct drivers of systemic pathogenesis in adult versus pediatric severe acute COVID-19

S Druzak, E Iffrig, BR Roberts, T Zhang… - Nature …, 2023 - nature.com
The pathogenesis of multi-organ dysfunction associated with severe acute SARS-CoV-2
infection remains poorly understood. Endothelial damage and microvascular thrombosis …