Immunoglobulin A (IgA) plays a key role in defending mucosal surfaces against attack by
infectious microorganisms. Such sites present a major site of susceptibility due to their vast …

Antiviral activities of antibodies may either be dependent only on interactions between the
antibody and cognate antigen, as in binding and neutralization of an infectious virion, or …

The central nervous system has historically been viewed as an immune-privileged site, but
recent data have shown that the meninges—the membranes that surround the brain and …

Immunoglobulin A (IgA) is the most abundant antibody class present at mucosal surfaces.
The production of IgA exceeds the production of all other antibodies combined, supporting …

HVTN 505 is a preventative vaccine efficacy trial testing DNA followed by recombinant
adenovirus serotype 5 (rAd5) in circumcised, Ad5-seronegative men and transgendered …

Antibody functions such as neutralization require recognition of antigen by the Fab region,
while effector functions are additionally mediated by interactions of the Fc region with …

Background: Extensive efforts have been made in optimizing monoclonal immunoglobulin
(Ig) G antibodies for use in clinical practice. Accumulating evidence suggests that IgA or anti …

Immunoglobulin (Ig) A is the most abundant antibody isotype present at mucosal surfaces
and the second most abundant in human serum. In addition to preventing pathogen entry at …

Decrypting the B cell ontogeny of HIV-1 broadly neutralizing antibodies (bNAbs) is
paramount for vaccine design. Here, we characterized IgA and IgG bNAbs of three distinct B …

Early humoral immune responses to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) are dominated by IgM and IgA antibodies, which greatly contribute to virus …