Spider-Venom Peptides: Structure, Bioactivity, Strategy, and Research Applications

R Guo, G Guo, A Wang, G Xu, R Lai, H Jin - Molecules, 2023 - mdpi.com
Spiders (Araneae), having thrived for over 300 million years, exhibit remarkable diversity,
with 47,000 described species and an estimated 150,000 species in existence. Evolving …

Peptide inhibitors of Kv1. 5: an option for the treatment of atrial fibrillation

J Borrego, A Feher, N Jost, G Panyi, Z Varga, F Papp - Pharmaceuticals, 2021 - mdpi.com
The human voltage gated potassium channel Kv1. 5 that conducts the IKur current is a key
determinant of the atrial action potential. Its mutations have been linked to hereditary forms …

Drug-targeted genomes: Mutability of ion channels and GPCRs

R Raines, I McKnight, H White, K Legg, C Lee, W Li… - Biomedicines, 2022 - mdpi.com
Mutations of ion channels and G-protein-coupled receptors (GPCRs) are not uncommon and
can lead to cardiovascular diseases. Given previously reported multiple factors associated …

Recombinant Expression in Pichia pastoris System of Three Potent Kv1.3 Channel Blockers: Vm24, Anuroctoxin, and Ts6

J Borrego, MU Naseem, ANA Sehgal, LR Panda… - Journal of Fungi, 2022 - mdpi.com
The Kv1. 3 channel has become a therapeutic target for the treatment of various diseases.
Several Kv1. 3 channel blockers have been characterized from scorpion venom; however …

Antimicrobial and Immunomodulatory Effects of Selected Chemokine and Antimicrobial Peptide on Cytokine Profile during Salmonella Typhimurium Infection in …

A Tuxpan-Pérez, MA Ibarra-Valencia, BE Estrada… - Antibiotics, 2022 - mdpi.com
The antimicrobial and immunomodulatory capacities of the peptide Css54 and the
chemokine MCP-1 were tested. The first, a peptide isolated from the venom of the scorpion …

Transcriptome-based analyses reveal venom diversity in two araneomorph spiders, Psechrus triangulus and Hippasa lycosina

W Yin, Y You, LR Tembrock, L Ding, C Zhang… - … and Physiology Part D …, 2023 - Elsevier
The spiders Psechrus triangulus and Hippasa lycosina are widely distributed in Yunnan
Province, China, and are important natural enemies of agricultural pests, yet studies …

The mechanism underlying toxicity of a venom peptide against insects reveals how ants are master at disrupting membranes

S Ascoët, A Touchard, N Téné, B Lefranc, J Leprince… - Iscience, 2023 - cell.com
Hymenopterans represent one of the most abundant groups of venomous organisms but
remain little explored due to the difficult access to their venom. The development of proteo …

Biochemical characterization and insecticidal activity of isolated peptides from the venom of the scorpion Centruroides tecomanus

MJ Bermúdez-Guzmán, JM Jiménez-Vargas… - Toxicon, 2022 - Elsevier
The venom of scorpions is a mixture of components that constitute a source of bioactive
molecules. The venom of the scorpion Centruroides tecomanus contains peptides toxic to …

Two Novel Mosquitocidal Peptides Isolated from the Venom of the Bahia Scarlet Tarantula (Lasiodora klugi)

J Ahmed, AA Walker, HD Perdomo, S Guo, SA Nixon… - Toxins, 2023 - mdpi.com
Effective control of diseases transmitted by Aedes aegypti is primarily achieved through
vector control by chemical insecticides. However, the emergence of insecticide resistance in …

[HTML][HTML] Current Technologies in Snake Venom Analysis and Applications

H Roman-Ramos, PL Ho - Toxins, 2024 - mdpi.com
This comprehensive review explores the cutting-edge advancements in snake venom
research, focusing on the integration of proteomics, genomics, transcriptomics, and …