Given the high attrition rates, substantial costs and slow pace of new drug discovery and
development, repurposing of'old'drugs to treat both common and rare diseases is …

Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in
regulating multiple signal transduction pathways that influence a diverse range of cellular …

Neuroinflammation is involved in the pathogenesis of amyotrophic lateral sclerosis (ALS),
but only limited data are available on systematic peripheral and central immune cell profiles …

Ras homolog (Rho)-associated kinases (ROCKs) belong to the serine-threonine kinase
family, which plays a pivotal role in regulating the damage, survival, axon guidance, and …

Background Fluoride, an environmental contaminant, is ubiquitously present in air, water,
and soil. It usually enters the body through drinking water and may cause structural and …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that causes the
progressive loss of motoneurons and, unfortunately, there is no effective treatment for this …

Neurodegenerative diseases are characterized by the progressive degeneration of neurons
in the central and peripheral nervous system (CNS, PNS), resulting in a reduced innervation …

Alzheimer's disease (AD) therapies predominantly focus on β-amyloid (Aβ), but Aβ effects
may be maximal before clinical symptoms appear. Downstream of Aβ, dendritic spine loss …

Background and Purpose Rho kinase (ROCK) activation is involved in neuroinflammatory
processes leading to progression of neurodegenerative diseases such as Parkinson's …

Rho-associated coiled-coil containing kinase isoform 2 (ROCK2) is a member of the AGC
family of serine/threonine kinases and an extensively studied regulator of actin-mediated …