[HTML][HTML] The Building Blocks of Antimicrobial Resistance in Pseudomonas aeruginosa: Implications for Current Resistance-Breaking Therapies

RF Langendonk, DR Neill, JL Fothergill - Frontiers in Cellular and …, 2021 - frontiersin.org
P. aeruginosa is classified as a priority one pathogen by the World Health Organisation, and
new drugs are urgently needed, due to the emergence of multidrug-resistant (MDR) strains …

[HTML][HTML] Overcoming intrinsic and acquired resistance mechanisms associated with the cell wall of gram-negative bacteria

RE Impey, DA Hawkins, JM Sutton… - Antibiotics, 2020 - mdpi.com
The global increase in multi-drug-resistant bacteria is severely impacting our ability to
effectively treat common infections. For Gram-negative bacteria, their intrinsic and acquired …

[HTML][HTML] Natural quorum sensing inhibitors effectively downregulate gene expression of Pseudomonas aeruginosa virulence factors

SAKS Ahmed, M Rudden, TJ Smyth… - Applied microbiology …, 2019 - Springer
At present, anti-virulence drugs are being considered as potential therapeutic alternatives
and/or adjuvants to currently failing antibiotics. These drugs do not kill bacteria but inhibit …

The resistome of Pseudomonas aeruginosa in relationship to phenotypic susceptibility

VN Kos, M Déraspe, RE McLaughlin… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Many clinical isolates of Pseudomonas aeruginosa cause infections that are difficult to
eradicate due to their resistance to a wide variety of antibiotics. Key genetic determinants of …

[HTML][HTML] Evolution of the Pseudomonas aeruginosa mutational resistome in an international Cystic Fibrosis clone

C López-Causapé, LM Sommer, G Cabot, R Rubio… - Scientific reports, 2017 - nature.com
Emergence of epidemic clones and antibiotic resistance development compromises the
management of Pseudomonas aeruginosa cystic fibrosis (CF) chronic respiratory infections …

[HTML][HTML] Can Biofilm Be Reversed Through Quorum Sensing in Pseudomonas aeruginosa?

S Yan, G Wu - Frontiers in microbiology, 2019 - frontiersin.org
Pseudomonas aeruginosa is a Gram-negative bacterium causing diseases in plants,
animals, and humans, and its drug resistance is a major concern in medical care. Biofilms …

Nosocomial infection and its molecular mechanisms of antibiotic resistance

J Xia, J Gao, W Tang - Bioscience trends, 2016 - jstage.jst.go.jp
Nosocomial infection is a kind of infection, which is spread in various hospital environments,
and leads to many serious diseases (eg. pneumonia, urinary tract infection, gastroenteritis …

Unexpected challenges in treating multidrug-resistant Gram-negative bacteria: resistance to ceftazidime-avibactam in archived isolates of Pseudomonas aeruginosa

ML Winkler, KM Papp-Wallace, AM Hujer… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Pseudomonas aeruginosa is a notoriously difficult-to-treat pathogen that is a common cause
of severe nosocomial infections. Investigating a collection of β-lactam-resistant P …

Prevalence of antibiotic resistance of Pseudomonas aeruginosa in cystic fibrosis infection: A systematic review and meta-analysis

P Bonyadi, NT Saleh, M Dehghani, M Yamini… - Microbial …, 2022 - Elsevier
Objective Pseudomonas aeruginosa is an opportunistic pathogen that infects the lungs of
people with cystic fibrosis (CF) and is the most common cause of chronic respiratory …

Antibiotic Resistance in Pseudomonas

P Laborda, S Hernando-Amado, JL Martínez… - … and Control Strategies, 2022 - Springer
Pseudomonas is a bacterial genus, with a bona fide environmental habitat that comprises
different species, some of them causing diseases in humans and plants, as well as some …