Considerations for the use of phage therapy in clinical practice

GA Suh, TP Lodise, PD Tamma… - Antimicrobial agents …, 2022 - Am Soc Microbiol
Increasing antimicrobial resistance and medical device-related infections have led to a
renewed interest in phage therapy as an alternative or adjunct to conventional …

Current challenges and future opportunities of phage therapy

DP Pires, AR Costa, G Pinto, L Meneses… - FEMS microbiology …, 2020 - academic.oup.com
Antibiotic resistance is a major public health challenge worldwide, whose implications for
global health might be devastating if novel antibacterial strategies are not quickly …

[HTML][HTML] Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era

H Ling, X Lou, Q Luo, Z He, M Sun, J Sun - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Antibiotic resistance is one of the biggest threats to global health, as it can make the
treatment of bacterial infections in humans difficult owing to their high incidence rate …

Bacteriophage-based advanced bacterial detection: Concept, mechanisms, and applications

W Hussain, MW Ullah, U Farooq, A Aziz… - Biosensors and …, 2021 - Elsevier
Some bacterial species are deadly disease-causing pathogens with high morbidity and
mortality in humans worldwide. Key interfaces in the transmission of bacterial pathogens …

Reassessment of historical clinical trials supports the effectiveness of phage therapy

L Marongiu, M Burkard, UM Lauer… - Clinical Microbiology …, 2022 - Am Soc Microbiol
Phage therapy has become a hot topic in medical research due to the increasing prevalence
of antibiotic-resistant bacteria strains. In the treatment of bacterial infections, bacteriophages …

Genetic determinants of host tropism in Klebsiella phages

B Beamud, N García-González, M Gómez-Ortega… - Cell reports, 2023 - cell.com
Bacteriophages play key roles in bacterial ecology and evolution and are potential
antimicrobials. However, the determinants of phage-host specificity remain elusive. Here, we …

Clinical Phage Microbiology: A suggested framework and recommendations for the in-vitro matching steps of phage therapy

D Gelman, O Yerushalmy, S Alkalay-Oren… - The Lancet …, 2021 - thelancet.com
Phage therapy is a promising solution for bacterial infections that are not eradicated by
conventional antibiotics. A crucial element of this approach is appropriate matching of …

gcplyr: an R package for microbial growth curve data analysis

M Blazanin - BMC bioinformatics, 2024 - Springer
Background Characterization of microbial growth is of both fundamental and applied
interest. Modern platforms can automate collection of high-throughput microbial growth …

Phage therapy for pulmonary infections: lessons from clinical experiences and key considerations

G Mitropoulou, A Koutsokera, C Csajka… - European …, 2022 - Eur Respiratory Soc
Lower respiratory tract infections lead to significant morbidity and mortality. They are
increasingly caused by multidrug-resistant pathogens, notably in individuals with cystic …

Towards Standardization of Phage Susceptibility Testing: The Israeli Phage Therapy Center “Clinical Phage Microbiology”—A Pipeline Proposal

O Yerushalmy, R Braunstein… - Clinical Infectious …, 2023 - academic.oup.com
Using phages as salvage therapy for nonhealing infections is gaining recognition as a
viable solution for patients with such infections. The escalating issue of antibiotic resistance …