Acute chest syndrome (ACS) is a leading cause of respiratory distress and hospitalisation in
children with sickle cell disease (SCD). The aetiology is multifactorial and includes fat …

Introduction: the spectrum of pulmonary complications in sickle cell anemia (SCA) comprises
mainly of acute chest syndrome (ACS), pulmonary hypertension (PH) and Airway hyper …

Background Sickle cell disease (SCD) is an inherited blood disorder that predominantly
affects individuals in sub-Saharan Africa. However, research that elucidates links between …

Sickle cell disease (SCD) is a life-threatening hereditary blood disorder that affects millions
of people worldwide, especially in sub-Saharan Africa. This condition has a multi-organ …

Background Pulmonary complications are common among children with sickle cell disease
(SCD). However, there is little literature on associated lung function abnormalities in …

Introduction Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by
the production of sickle hemoglobin, leading to red blood cells sickling and hemolysis in …

Rationale: Chronic lung injury is common in sickle cell anemia (SCA) and worsens
outcomes. Sensitive lung function tests might predict reversible disease that might benefit …

Early-life determinants, such as passive smoking, indoor air pollution, childhood infections,
nutritional status, and socioeconomic status (SES), affect lung development and the …

Sickle cell disease (SCD) is of global significance due to its severity and occurrence
worldwide. Inheritance of the abnormal hemoglobin structure contributes to microvascular …

Background Among inherited blood diseases, sickle cell disease (SCD) is the most
common, and its prevalence is rising worldwide. People with SCD often have abnormal lung …