Recent advances in biological active sulfonamide based hybrid compounds Part A: Two-component sulfonamide hybrids
Sulfonamides constitute an important class of drugs, with many types of pharmacological
agents possessing antibacterial, anti-carbonic anhydrase, anti-obesity, diuretic …
agents possessing antibacterial, anti-carbonic anhydrase, anti-obesity, diuretic …
Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo …
MM Khalifa, AA Al-Karmalawy, EB Elkaeed… - Journal of Enzyme …, 2022 - Taylor & Francis
This research presents the design and synthesis of a novel series of phthalazine derivatives
as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new …
as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new …
Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 …
A Belal, NM Abdel Gawad, ABM Mehany… - Journal of enzyme …, 2022 - Taylor & Francis
A new series of 1 H-pyrrole (6a–c, 8a–c), pyrrolo [3, 2-d] pyrimidines (9a–c) and pyrrolo [3, 2-
e][1, 4] diazepines (11a–c) were designed and synthesised. These compounds were …
e][1, 4] diazepines (11a–c) were designed and synthesised. These compounds were …
4-(5-Amino-pyrazol-1-yl) benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and …
In the current medical era, the single target inhibition paradigm of drug discovery has given
way to the multi-target design concept. As the most intricate pathological process …
way to the multi-target design concept. As the most intricate pathological process …
3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and …
Herein we describe the design and synthesis of two series of sulfonamides featuring N-
unsubstituted (4a-c) or N-substituted (7a-o) isatin moieties (as tails) connected to …
unsubstituted (4a-c) or N-substituted (7a-o) isatin moieties (as tails) connected to …
3-Methylthiazolo [3, 2-a] benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis …
Herein we describe design and synthesis of different series of novel small molecules
featuring 3-methylthiazolo [3, 2-a] benzimidazole moiety (as a tail) connected to the zinc …
featuring 3-methylthiazolo [3, 2-a] benzimidazole moiety (as a tail) connected to the zinc …
Structure activity relationship of key heterocyclic anti-angiogenic leads of promising potential in the fight against cancer
Pathological angiogenesis is a hallmark of cancer; accordingly, a number of anticancer FDA-
approved drugs act by inhibiting angiogenesis via different mechanisms. However, the …
approved drugs act by inhibiting angiogenesis via different mechanisms. However, the …
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro …
In the present study, we report the design and synthesis of novel CAN508 sulfonamide-
based analogues (4, 8a-e, 9a-h and 10a-e) as novel carbonic anhydrase (CA) inhibitors with …
based analogues (4, 8a-e, 9a-h and 10a-e) as novel carbonic anhydrase (CA) inhibitors with …
Discovery of 4-alkoxy-2-aryl-6, 7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity
In our attempt to develop potential anticancer agents targeting Topoisomerase I (TOP1), two
novel series of 4-alkoxy-2-arylquinolines 14a-p and 19a-c were designed and synthesized …
novel series of 4-alkoxy-2-arylquinolines 14a-p and 19a-c were designed and synthesized …
[HTML][HTML] Optimization of pyrazolo [1, 5-a] pyrimidine based compounds with pyridine scaffold: Synthesis, biological evaluation and molecular modeling study
MA Abdelgawad, NAA Elkanzi, A Musa… - Arabian Journal of …, 2022 - Elsevier
Background Pyrazolopyrimidine heterocycle and its isosteres represent the main scaffold for
many pharmacologically active drugs including anti-inflammatory agents. The COX-2 …
many pharmacologically active drugs including anti-inflammatory agents. The COX-2 …