Cancer drug resistance represents the main obstacle in cancer treatment. Drug-resistant
cancers exhibit complex molecular mechanisms to hit back therapy under pharmacological …

RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …

Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a
potential cancer therapeutic. However, the mechanisms underlying the initiation …

Apoptosis is the natural programmed cell death process, which is responsible for abnormal
cell clearance. However, many cancer cells develop various mechanisms to escape …

Sorafenib, a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC),
has been shown to be a potent ferroptosis inducer in HCC. However, we found that there …

Gastric carcinoma is a highly malignant tumor that still lacks effective molecular targets.
Heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) is an essential oncogenic …

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) serve essential biological
functions as post-transcriptional performers, participating in the acquisition or maintenance …

As the representative item of environmental chemical carcinogen, MNNG was closely
associated with the onset of Gastric cancer (GC), while the underlying mechanisms remain …

Extracellular vesicles (EVs), including exosomes, play a crucial role in intercellular
communication and have emerged as important mediators in the development and …

Abstract N6-methyladenosine (m6A) methylation, the most prevalent and abundant RNA
modification in eukaryotes, has recently become a hot research topic. Several studies have …