Sleep state switching
We take for granted the ability to fall asleep or to snap out of sleep into wakefulness, but
these changes in behavioral state require specific switching mechanisms in the brain that …
these changes in behavioral state require specific switching mechanisms in the brain that …
Physiologically-based modeling of sleep–wake regulatory networks
Mathematical modeling has played a significant role in building our understanding of sleep–
wake and circadian behavior. Over the past 40 years, phenomenological models, including …
wake and circadian behavior. Over the past 40 years, phenomenological models, including …
Mathematical models for sleep-wake dynamics: comparison of the two-process model and a mutual inhibition neuronal model
Sleep is essential for the maintenance of the brain and the body, yet many features of sleep
are poorly understood and mathematical models are an important tool for probing proposed …
are poorly understood and mathematical models are an important tool for probing proposed …
Sleep–wake regulation in preterm and term infants
A Georgoulas, L Jones, MP Laudiano-Dray, J Meek… - Sleep, 2021 - academic.oup.com
Abstract Study Objectives In adults, wakefulness can be markedly prolonged at the expense
of sleep, eg to stay vigilant in the presence of a stressor. These extra-long wake bouts result …
of sleep, eg to stay vigilant in the presence of a stressor. These extra-long wake bouts result …
[HTML][HTML] Circuit mechanisms and computational models of REM sleep
Rapid eye movement (REM) sleep or paradoxical sleep is an elusive behavioral state. Since
its discovery in the 1950s, our knowledge of the neuroanatomy, neurotransmitters and …
its discovery in the 1950s, our knowledge of the neuroanatomy, neurotransmitters and …
A mathematical model towards understanding the mechanism of neuronal regulation of wake-NREMS-REMS states
In this study we have constructed a mathematical model of a recently proposed functional
model known to be responsible for inducing waking, NREMS and REMS. Simulation studies …
model known to be responsible for inducing waking, NREMS and REMS. Simulation studies …
GABA-to-ACh ratio in basal forebrain and cerebral cortex varies significantly during sleep
Abstract Study Objectives: GABAergic and cholinergic transmission within the basal
forebrain and cerebral cortex contribute to the regulation of sleep and wakefulness. In …
forebrain and cerebral cortex contribute to the regulation of sleep and wakefulness. In …
Progressive loss of the orexin neurons reveals dual effects on wakefulness
AF Branch, W Navidi, S Tabuchi, A Terao, A Yamanaka… - Sleep, 2016 - academic.oup.com
Abstract Study Objectives: Narcolepsy is caused by loss of the orexin (also known as
hypocretin) neurons. In addition to the orexin peptides, these neurons release additional …
hypocretin) neurons. In addition to the orexin peptides, these neurons release additional …
A thalamocortical neural mass model of the EEG during NREM sleep and its response to auditory stimulation
M Schellenberger Costa, A Weigenand… - PLoS computational …, 2016 - journals.plos.org
Few models exist that accurately reproduce the complex rhythms of the thalamocortical
system that are apparent in measured scalp EEG and at the same time, are suitable for large …
system that are apparent in measured scalp EEG and at the same time, are suitable for large …
Activation of inactivation process initiates rapid eye movement sleep
Interactions among REM-ON and REM-OFF neurons form the basic scaffold for rapid eye
movement sleep (REMS) regulation; however, precise mechanism of their activation and …
movement sleep (REMS) regulation; however, precise mechanism of their activation and …